Epidemics III

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“If history is our guide, we can assume that the battle between the intellect and will of the human species and the extraordinary adaptability of microbes will be never-ending.” (1)

Despite all the remarkable technological breakthroughs that we have made over the past few decades, the threat from infectious diseases has significantly accelerated. In this course, we will learn why this is the case by looking at the fundamental scientific principles underlying epidemics and the public health actions behind their prevention and control in the 21st century.

This is the third (control of infectious diseases) of the four courses, covers these topics:

  • Disease Surveillance
  • Non-pharmaceutical intervention (NPI)
  • Vaccination (Effectiveness, Trials, Safety, Impact on Populations, Vaccine Economics, Confidence and Hesitancy)
  • Panel Discussion on WHO’s Response to the Ebola Outbreak; and Anti-vaccination



这是四個课程中的第三个(傳染病的控制), 涵盖以下主题:

  • 疾病监测
  • 非药物干预
  • 疫苗 (效果, 试验, 安全性, 对人群的影响, 疫苗经济学, 信心和犹豫)
  • 專家专题讨论: 世界卫生组织对埃博拉疫情的应对;和反疫苗行动


(1) Fauci AS, Touchette NA, Folkers GK. Emerging Infectious Diseases: a 10-Year Perspective from the National Institute of Allergy and Infectious Diseases. Emerg Infect Dis 2005 Apr; 11(4):519-25.


Week 1: Control (Disease surveillance)

  • Disease Surveillance Overview
  • Emerging Infections and Outbreak Detection
  • Syndromic Surveillance
  • Serologic Surveillance
  • Surveillance - Evaluation of Control Measures (Control Studies)
  • Surveillance - Evaluation of Control Measures (Active and Passive Surveillance)
  • Surveillance - Evaluation of Control Measures (Vaccine Effectiveness)
  • Supplementary Module: Harnessing Multinational Data Sources in Global Models to Inform Vaccine Policy

Week 2: Control (Non-pharmaceutical intervention (NPI))

  • Non-pharmaceutical Interventions Overview and John Snow
  • Control of Cholera
  • Hygiene and Other Personal Interventions
  • Isolation and Quarantine and Contact Tracing
  • School Closure
  • International Measures Including Travel Restrictions and Entry Screening
  • Zoonoses - Market Closure

Week 3: Panel Discussion on WHO’s Response to the Ebola Outbreak

  • The Stocking Report
  • Outbreak Alert and Emergency Response
  • WHO Preparedness Centres
  • Ebola Vaccine
  • Health System Infrastructure
  • Lessons Learned
  • Communication Strategy

Week 4: Control (Vaccination)

  • Brief History and Current Issues
  • How Vaccines Work
  • Herd Immunity and Other Indirect Benefit
  • How to Measure Vaccine Effect
  • Vaccine Trials
  • Safety
  • Influenza Vaccines
  • Measuring Vaccine Impact on Populations
  • Vaccine Economics
  • Introducing a New Vaccine

Week 5: Panel Discussion on Anti-vaccination, and Supplementary Module on Next Generation Informatics for Global Health

  • The State of Vaccine Confidence
  • Vaccine Confidence and Hesitancy
  • Trust
  • Measles Vaccine
  • Experimental Vaccines: Ebola
  • Vaccination: a basic health right?
  • Supplementary Module: Digital Health & Epidemiology